Decrease in the Number of Erythrogenic Elements in the Blood-Forming Tissues as the Cause of Anemia in Hypophysectomized Rats

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Abstract
Male rats weighing 400 g were hypophysectomized, and erythropoietic marrow distribution, determination of number of erythroid cells in marrow and spleen, and iron kinetic studies were done 75-85 days after hypophysectomy. Rats of the same age served as normal controls. Positron camera pictures of the distribution of erythropoietic marrow within the skeleton using Fe52 showed the erythroid marrow of the hypophysectomized rats to be concentrated in the thoracic and lumbar spine, with less erythropoietic marrow in the extremities and proximal caudal vertebrae than in the controls. Total number of nucleated erythroid cells in marrow plus spleen, red cell mass, and rate of hemoglobin synthesis per 100 g of body weight in hypophysectomized rats were approximately 55% of the values in normal rats. The estimated mean erythron life span and mean effective erythron hemoglobinization time were similar in the 2 groups studied. It is concluded that erythro-poiesis is decreased in the long-term hypophysectomized rat because of a decrease in the number of erythrogenic elements in the blood-forming tissues.

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