Successful program to prevent aspergillus infections in children undergoing marrow transplantation: use of nasal amphotericin
- 1 January 1997
- journal article
- research article
- Published by Springer Nature in Bone Marrow Transplantation
- Vol. 19 (1) , 43-47
- https://doi.org/10.1038/sj.bmt.1700618
Abstract
Aspergillus infections in pediatric bone marrow transplant (BMT) patients are usually fatal. We began the use of a prophylactic nasal spray of amphotericin in 1990. This nasal spray was provided in addition to low-dose intravenous amphotericin. During the time of this study, the number of fatal cases of aspergillus in the pediatric BMT population was reduced significantly from 13.8% to 1.8% (P < 0.0025) thereby suggesting that the use of nasal amphotericin in this population helps to prevent fatal aspergillus infections. the lack of significant side-effects and the ease of administration make this a very helpful preventive measure in the supportive care of pediatric bone marrow transplant patients.Keywords
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