Immunocytochemical Demonstration of Intranuclear Localization of 18S Gamma Macroglobulin in Macroglobulinemia of Waldenstrom

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Abstract
Immunofluorescent and cytochemical technique were used to identify 18S gamma macroglobulin within the nucleus and cytoplasm of lymphocytoid plasma cells from a patient with macroglobulinemia of Waldenstrom. Intranuclear fluorescence coincided with presence of intranuclear periodic acid- Schiff positive protein. This observation supports the concept, suggested by histochemical studies, that circulating macroglobulin and intranuclear protein of lymphocytoid plasma cells are closely related and may be identical. The evidence suggests that macroglobulin is formed in lymphocytoid plasma cells.

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