Cholecystokinin Receptors in the Brain: Characterization and Distribution
- 6 June 1980
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 208 (4448) , 1155-1156
- https://doi.org/10.1126/science.6246582
Abstract
Specific cholecystokinin binding sites in particulate fractions of rat brain were measured with iodine 125-labeled Bolton-Hunter cholecystokinin, a cholecystokinin analog that has full biological activity. Binding was detected in brain regions known to contain immunoreactive cholecystokinin. Binding was saturable, reversible, of high affinity (dissociation constant, 1.7 x 10(-9) M), and was inhibited by cholecystokinin analogs but not by unrelated hormones.Keywords
This publication has 26 references indexed in Scilit:
- Peptides as neurotransmitter candidates in the mammalian cnsProgress in Neurobiology, 1979
- Brain cholecystokinin and nutritional status in rats and mice.Journal of Clinical Investigation, 1979
- Cholecystokinin in the Brains of Obese and Nonobese MiceScience, 1979
- Isolation, structure and biological activity of two cholecystokinin octapeptides from sheep brainNature, 1978
- Insulin receptors are widely distributed in the central nervous system of the ratNature, 1978
- Immunoreactive component resembling cholecystokinin octapeptide in intestineNature, 1977
- Peptides in brain and intestineNature, 1976
- MODULATION OF PITUITARY RESPONSIVENESS TO EXOGENOUS LHRH BY AN OESTROGENIC AND AN ANTI‐OESTROGENIC COMPOUND IN THE NORMAL MALEClinical Endocrinology, 1976
- FURTHER INVESTIGATIONS ON INTESTINAL HORMONAL POLYPEPTIDESClinical Endocrinology, 1976
- THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONSAnnals of the New York Academy of Sciences, 1949