THE EFFECT OF PITUITARY STALK-SECTION ON THE REPRODUCTIVE ORGANS OF FEMALE RATS1

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Abstract
Ovarian hypoactivity always appeared in rats after sectioning of the pituitary stalk by the parapharyngeal approach. Vaginal cycles were absent or irregular, ovarian and uterine weights were less than normal, and the vaginal epithelium was atrophic. Histological sections of the ovaries revealed general atrophy. The hypopituitary state reflected by these changes correlated well with the fibrosis and cellular alterations observed in histological sections of pituitary glands of these animals. These results are believed to be due to ischemia as a result of interruption of blood vessels of the pituitary traversing the stalk. Ensuing pituitary function may be dependent on the extent of the vascular insult and of subsequent revascularization. Revascularization, whatever its source, was not due to regeneration of the portal blood vessels.

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