Blood and tissue distribution of cyclosporin A after a single oral dose in the rat
- 1 June 1984
- journal article
- research article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 40 (6) , 559-561
- https://doi.org/10.1007/bf01982329
Abstract
After a single oral dose of cyclosporin A (82 mg/kg) in rats, tissue (kidneys liver and brain) and blood levels reached maximum values (approximately 80 μg/g and 3.5 μg/ml) between 3 and 7 h after drug administration. Drug elimination continued for at least 5 days. The 24-h urine and bile elimination was 2% for each.Keywords
This publication has 14 references indexed in Scilit:
- Nephrotoxicity in bone marrow transplant recipients treated with cyclpsporin ABritish Journal of Haematology, 1983
- ACUTE RENAL TOXICITY WITH COMBINED USE OF AMPHOTERICIN B AND CYCLOSPORINE AFTER MARROW TRANSPLANTATIONTransplantation, 1983
- CYCLOSPORIN-A TO PREVENT GRAFT-VERSUS-HOST DISEASE - A PILOT-STUDY IN 22 PATIENTS RECEIVING ALLOGENEIC MARROW TRANSPLANTS1983
- CYCLOSPORIN A TISSUE LEVELS IN A CADAVERIC RENAL ALLOGRAFT RECIPIENTTransplantation, 1983
- Nephrotoxicity of Cyclosporin a after Allogeneic Marrow TransplantationNew England Journal of Medicine, 1981
- Liver Transplantation with Use of Cyclosporin a and PrednisoneNew England Journal of Medicine, 1981
- A Radioimmunoassay to Measure Cyclosporin a in Plasma and Serum SamplesJournal of Immunoassay, 1981
- CYCLOSPORIN A TO PREVENT GRAFT-VERSUS-HOST DISEASE IN MAN AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATIONThe Lancet, 1980
- CYCLOSPORIN A INITIALLY AS THE ONLY IMMUNOSUPPRESSANT IN 34 RECIPIENTS OF CADAVERIC ORGANS: 32 KIDNEYS, 2 PANCREASES, AND 2 LIVERSThe Lancet, 1979
- CYCLOSPORIN ATransplantation, 1979