Immunologic Response of Guinea Pigs to Infection with Angiostrongylus cantonensis

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Abstract
Guirxea pigs infected witlt Angiostrongylus cantonensis were examined forthe occttrrence of antigen sensitixe lymphocytes in variotns lymphoid organs (cervical, mediastinal and mesenteric l)mph nodes, and spleen), as assessed by in vitro incorpora-Lion of tritiated thymidine by lymphocytes following stimulation by adult or young adultworm antigens.Only splenic cells from infected guinea pigs showved significant blastogenic responses toboth adult and young adult worm antigens throtughout the course of infection. Thisresponse gradually increased as the infection progressed.Homocytotropic reaginic antibody was first detected 18 days postinfection and continu-ously demonstrated in some individuals throughout 18 to 47 days postinfection. However, the production of reaginic antibody was observed in only 50% (5/10) of the infectedanimals.No hemagglutinating antibody could be observed in the infected animals during thecourse of infection.

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