Isozyme variations in acetaldehyde dehydrogenase (E.C.1.2.1.3) in human tissues

1 January 1978

journal article
research article
Published by Springer Nature in Human Genetics

Vol. 44 (2) , 181-185
https://doi.org/10.1007/bf00295411

Abstract

NAD-dependent acetaldehyde dehydrogenase (ALDH) of human tissues was investigated by electrophoresis and enzyme assay. ALDH is located mainly in the liver and kidney. The isozymes consist of at least six different components. Five different phenotypes were found in a total of 68 human liver and kidney specimens. It is likely that three isozyme sets are concerned in determining ALDH types. The distribution of various phenotypes of ALDH isozyme sets is presented.

Keywords

ENZYME

This publication has 7 references indexed in Scilit:

Human liver alcohol dehydrogenase isoenzyme variations
Human Genetics, 1978
Liver alcohol dehydrogenase in Japanese: high population frequency of atypical form and its possible role in alcohol sensitivity.
1975
Studies on the properties of the human alcohol dehydrogenase isozymes determined by the different loci ADH₁, ADH₂, ADH₃
Annals of Human Genetics, 1973
Aldehyde dehydrogenase activity in a rat hepatoma
Biochemical and Biophysical Research Communications, 1972
Mechanism of the inhibition of aldehyde dehydrogenase in vivo by disulfiram and diethyldithiocarbamate.
1971
Developmental changes and polymorphism in human alcohol dehydrogenase
Annals of Human Genetics, 1971
Phosphoglucomutase Polymorphism in Man
Nature, 1964