HIGH-RISK PREMATURITY - PROGESTIN TREATMENT AND STEROID STUDIES

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  • 1 January 1979
    • journal article
    • research article
    • Vol. 54  (4) , 412-418
Abstract
Studies were undertaken regarding the efficacy and modus operandi of 17.alpha.-hydroxyprogesterone caproate (17.alpha.-OHP-C) in preventing premature labor in high-risk patients. Of 70 patients, the treated patient population had a prematurity rate (12.8%) and a perinatal mortality rate (5%) which were significantly lower than those of the total placebo or untreated patient group (40.9 and 25%, respectively). Sequential plasma steroid values were determined in 21 patients, 10 of whom delivered prematurely. Low plasma progesterone (P) and 17.alpha.-hydroxyprogesterone (17.alpha.-OHP) levels evidently precede the onset of preterm labor by weeks. Successful treatment with 17.alpha.-OHP-C was characterized by elevated P levels. Plasma estradiol and cortisol values did not vary with time of delivery or treatment. The progesterone block theory is supported as an important mechanism affecting preterm delivery in this high-risk population.

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