DEVELOPMENT OF A CARDIAC ANTI-ARRHYTHMIC SCREENING-TEST UTILIZING THEOPHYLLINE IN THE RAT

  • 1 January 1980
    • journal article
    • research article
    • Vol. 243  (1) , 86-96
Abstract
Cardiac arrhythmias were produced in Sprague-Dawley derived rats by chloroform challenge. The incidence of cardiac arrhythmias so induced increased with age and as a function of dose after pretreatment with theophylline. The dose-response and time-action parameters of theophylline''s predisposing action to chloroform-hypoxia-induced cardiac arrhythmias were determined. This information was used to develop a cardiac antiarrhythmic screening test in unanesthetized rats which is presented in the following paper.

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