RUNNING INTERFERENCE: Prospects and Obstacles to Using Small Interfering RNAs as Small Molecule Drugs
- 1 August 2006
- journal article
- review article
- Published by Annual Reviews in Annual Review of Biomedical Engineering
- Vol. 8 (1) , 377-402
- https://doi.org/10.1146/annurev.bioeng.8.061505.095848
Abstract
RNA interference (RNAi) is a well-conserved, ubiquitous, endogenous mechanism that uses small noncoding RNAs to silence gene expression. The endogenous small RNAs, called microRNAs, are pro...Keywords
This publication has 128 references indexed in Scilit:
- TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencingNature, 2005
- Structural basis for 5′-end-specific recognition of guide RNA by the A. fulgidus Piwi proteinNature, 2005
- Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA TargetsCell, 2005
- Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacyNature Biotechnology, 2004
- The Microprocessor complex mediates the genesis of microRNAsNature, 2004
- Processing of primary microRNAs by the Microprocessor complexNature, 2004
- The role of RNA interference in heterochromatic silencingNature, 2004
- RNA Interference in Mammalian Cells by Chemically-Modified RNABiochemistry, 2003
- Induction of an interferon response by RNAi vectors in mammalian cellsNature Genetics, 2003
- Expression profiling reveals off-target gene regulation by RNAiNature Biotechnology, 2003