SERUM HYDROCORTISONE (CORTISOL) VALUES IN NORMAL AND ADRENOPATHIC DOGS AS DETERMINED BY RADIOIMMUNOASSAY

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 39  (1) , 179-181
Abstract
Using a specific radioimmunoassay, serum hydrocortisone values were measured in dogs. Between 9:00 a.m. and 10:00 a.m. the baseline hydrocortisone value for 56 clinically normal dogs ranged from 6.0-28.5 ng/ml, with a mean value of 17.8 .+-. 1.32 ng/ml (mean .+-. SEM [standard error of the mean]). Marked differences due to age, sex, body wt, or breed were not observed in the hydrocortisone values. In 11 dogs with definitive hyperadrenocorticism, serum hydrocortisone values ranged 32-148 ng/ml. In 2 dogs with hypoadrenocorticism, the values were 4.5 and 3.1 ng/ml. The estimation of serum hydrocortisone values by radioimmunoassay is simple and precise, and can be utilized to aid in the diagnosis of adrenopathy in dogs.