Interactions between Immune‐Stimulating Complexes (ISCOMs) and Peritoneal Mononuclear Leucocytes
- 1 February 1992
- journal article
- Published by Wiley in Microbiology and Immunology
- Vol. 36 (2) , 199-203
- https://doi.org/10.1111/j.1348-0421.1992.tb01657.x
Abstract
Studies were undertaken in mice using immune-stimulating complexes (ISCOMs) or micelles prepared from envelope glycoproteins of human influenza virus (PR8) and matrix (i.e., ISCOM skeleton without incorporated antigen). Electron microscopic studies showed that ISCOMs, in contrast to micelles, have a remarkable affinity for cell membranes and seem to rapidly promote their own internalization by cells to which they adhere. PR8 ISCOMs, but not matrix nor micelles, significantly increased the expression of membrane Ia by peritoneal mononuclear leucocytes 24 hr after intraperitoneal immunization.Keywords
This publication has 6 references indexed in Scilit:
- Effect of iscoms and their adjuvant moiety (matrix) on the initial proliferation and IL-2 responses: Comparison of spleen cells from mice inoculated with iscoms and/or matrixCellular Immunology, 1990
- Inflammatory response and antigen localization following immunization with influenza virus ISCOMsInflammation, 1989
- ISCOMs and Immunostimulation with Viral AntigensPublished by Springer Nature ,1989
- The ISCOM: an immunostimulating complexImmunology Today, 1987
- Iscom, a novel structure for antigenic presentation of membrane proteins from enveloped virusesNature, 1984
- Action of Saponin on Biological Cell MembranesNature, 1962