Early lymphocyte recovery after autologous stem cell transplantation predicts superior survival in mantle-cell lymphoma

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Abstract
Autologous stem cell transplantation (ASCT) is an effective treatment strategy for mantle-cell lymphoma (MCL) demonstrating significantly prolonged progression-free survival (PFS) when compared to interferon- maintenance therapy of patients in first remission. The study of absolute lymphocyte count at day 15 (ALC-15) after ASCT as a prognostic factor in non-Hodgkin lymphoma (NHL) included different lymphoma subtypes. The relationship of ALC-15 after ASCT in MCL has not been specifically addressed. We evaluated the impact of ALC-15 recovery on survival of MCL patients undergoing ASCT. We studied 42 consecutive MCL patients who underwent ASCT at the Mayo Clinic in Rochester from 1993 to 2005. ALC-15 threshold was set at 500 cells/l. The median follow-up after ASCT was 25 months (range, 2–106 months). The median overall survival (OS) and PFS times were significantly better for the 24 patients who achieved an ALC-15 500 cells/l compared with 18 patients with ALC-15 l (not reached vs 30 months, PPl is associated with a significantly improved clinical outcome following ASCT in MCL.

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