Further Studies on Species Differences in Follicle Stimulating Hormone as Revealed by the Slope in the Steelman-Pohley Assay1

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Abstract
Follicle stimulating hormone from bovine and canine pituitaries and human postmenopausal urine was tested by the HCG-augmentation bio-assay of Steelman and Pohley. When 2 daily injections were used, the slopes for FSH from any source were not significantly different. Decreasing the number of daily injections from 2 to 1 did not significantly affect the slope for urinary FSH, but did significantly decrease the slope for canine pituitary FSH. Bovine pituitary FSH was unique in that a similar decrease effectively abolished the slope of its dose-response curve.