203Hg Excretion and Tissue Distribution in Holstein Calves following Single Tracer Intravenous Doses of Methyl Mercury Chloride or Mercuric Chloride

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Abstract
Eight male Holstein calves were given a single tracer intravenous dose of 203Hg as mercuric chloride or methyl mercury chloride 7 days before sacrifice. Total 7-day fecal and urinary 203Hg excretions were much higher (P < .01) from mercuric chloride dosing (28.3 and 8.1% of the dose) than from methyl mercury chloride (6.1 and .4% of the dose). Retention of 203Hg from mercuric chloride was 2–8 times greater (P < .01) in kidney, liver, spleen, lung, testicle, rib shaft, tibia joint, tibia shaft, abomasum, small intestine, cecum and large intestine and higher (P < .05) in pancreas. In contrast, 203Hg from mercuric chloride was lower (P < .01) in brain cerebellum and cerebrum, supraspinatus muscle and heart, and substantially lower (P < .05) in psoas and semitendinosus muscles. Fifteen minutes after dosing, whole blood 203Hg was lower (P < .01) from mercuric chloride followed by a similar rapid clearance for both 203Hg forms. Throughout the 7-day period, plasma 203Hg was greater (P < .01) from mercuric chloride. In red blood cells, 203Hg from methyl mercury chloride was higher (P < .01) during the first 2 hr after dosing, with no significant differences thereafter. Copyright © 1975. American Society of Animal Science . Copyright 1975 by American Society of Animal Science.

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