THE NEUROMUSCULAR BLOCKING ACTION OF PANCURONIUM IN MAN DURING ANAESTHESIA

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Abstract
The neuromuscular blocking action of pancuronium bromide was investigated in anaesthetized patients. Pancuronium resembles tubocurarine in producing a competitive type block but is about five times as potent as tubocurarine. With a small dose (0.02 mg/kg) the onset of action of the drug was slow, with the time to its maximum effect averaging 4.5 minutes. The maximum effect was, on average, a reduction in twitch height of 69 per cent. With larger doses of the agent (0.05 mg/kg and 0.1 mg/kg) the onset was more rapid and usually a complete block was achieved. The recovery from 0.02 mg/kg and 0.05 mg/kg to 50 per cent of the initial twitch height averaged 12.2 minutes and 36.8 minutes respectively. Repeated doses of the drug produced a greater duration of action with a somewhat greater intensity of block. During recovery from the action of the drug a respiratory acidaemia reduced and a respiratory alkalaemia increased the rate of recovery.

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