Preliminary Evaluation of Animal Systemic Insecticides

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Abstract
When 17 compounds were found to be active as systemic insecticides in preliminary laboratory tests with guinea pigs, tests were conducted by treating small numbers of cattle with these compounds and Bayer 23129 ( O,O -dimethyl S -2(ethylthio) ethyl phosphorodithioate) to determine their systemic effect against cattle grubs ( Hypoderma spp.). Bayer 29493, Dowco 105, and Stauffer R-2371 gave 95% to 100% control of grubs at dosages tolerated by the cattle. The rest were ineffective or inconsistently effective or effective at dosages toxic to cattle. The chemical names of the effective compounds are Bayer 29493 ( O,O -dimcthyl O -(4-methylthio- m -tolyl) phosphorothioate), Dowco 105 ( O -(4- tert -butyl-2-dllorophenyl) O -methyl ethylphosphoramidothioate), and Stauffer R-2371 ( O,O -diethyl bis-(4-chlorophenyl) methyl phosphorodithioate).

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