ANALGESIC ACTIVITY OF DIPIPANONE HYDROCHLORIDE IN STUDENT VOLUNTEERS
Open Access
- 1 March 1957
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology and Chemotherapy
- Vol. 12 (1) , 97-99
- https://doi.org/10.1111/j.1476-5381.1957.tb01368.x
Abstract
Dipipanone hydrochloride raised the threshold to ischaemic pain in healthy human volunteers. The lowest dose producing a significant rise in pain threshold was 10.0 mg. The peak effect for all doses was reached after about 2 hr. Side effects, the most common of which were drowsiness, nausea, and vertigo, are described and analysed. The drug was shown to be a histamine liberator and to cause pain and tenderness at injection sites.Keywords
This publication has 1 reference indexed in Scilit:
- The assay of analgesic drugs on manThe Analyst, 1952