PHARMACOLOGICAL PROPERTIES OF AXONAL SODIUM-CHANNELS IN THE COCKROACH PERIPLANETA-AMERICANA L .2. SLOWING OF SODIUM CURRENT TURN-OFF BY CONDYLACTIS TOXIN

  • 1 January 1979
    • journal article
    • research article
    • Vol. 83  (DEC) , 49-58
Abstract
Condylactis toxin induces a prolonged falling phase in action potentials recorded from giant axons of the cockroach P. americana L. A distinct plateau potential can be recorded in the presence of Condylactis toxin at concentrations of 0.5 mg/ml and above. In cockroach axons, voltage-clamp experiments show that Condylactis toxin acts primarily by slowing the Na current turn-off without affecting either the time-course of the Na conductance increase or the peak amplitude of the transient Na current.

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