Homozygous factor-V mutation as a genetic cause of perinatal thrombosis and cerebral palsy
- 1 November 1999
- journal article
- case report
- Published by Wiley in Developmental Medicine and Child Neurology
- Vol. 41 (11) , 777-780
- https://doi.org/10.1017/s0012162299001541
Abstract
A 5-year old girl with cerebral palsy (CP), preterm birth, postnatal aortic thrombus, and cerebellar venous infarction who is homozygous for the thrombophilic factor-V Leiden (fVL) mutation is reported. The role of hereditary thrombophilic disorders in the development of perinatal vascular lesions such as aortic thrombi, renal-vein thrombosis, venous-sinus thrombosis, and cerebral infarction is unknown. This case report brings into question a potential association between fVL, perinatal vascular lesions, perinatal stroke, and CP.Keywords
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