Hemophilia A and Concurrent Factor VII Deficiency

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Abstract
THE number of adequately documented cases of congenital deficiency of two clotting factors is small; the association of antihemophilic factor and factor VII deficiency is particularly rare. Constandoulakis1 reported a family in which 2 males with hemophilia had mildly abnormal one-stage prothrombin times that could be corrected by normal plasma, but not by aluminum hydroxide adsorbed plasma or serum deficient in factor VII that was not specifically stated to be congenitally deficient. Owren factor VII complex assays were 40 and 50 per cent of normal in the 2 patients. Deficiency of antihemophilic factor was diagnosed by the thromboplastin-generation test. Prothrombin . . .