Characterization of two sequential polytripeptides containing glycine and ethyl‐glutamate residues
- 1 July 1972
- journal article
- research article
- Published by Wiley in Biopolymers
- Vol. 11 (7) , 1411-1419
- https://doi.org/10.1002/bip.1972.360110709
Abstract
The polytripeptides poly(glu(OEt)‐gly‐gly) and poly(glu(OEt)‐glu(OEt)‐gly) have been synthesized and characterized using infrared linear dichroism, ultraviolet circular dichroism spectroscopy, and electron microscopy. Both polymers have been obtained in a cross β conformation with antiparallel chains, however, there appear to be significant differences in the stability of this conformation for the two polymers. Poly(glu(OEt)‐gly‐gly) has also been shown to exist in a 31 polyglycine II type helix in aqueous solution whereas films cast from this solution appear to be random. Finally this same polymer can be obtained in either a random or an extended form trifluoroacetic acid depending on the nature of the substrate used for film casting.Keywords
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