METHYSERGIDE, RETROPERITONEAL FIBROSIS AND RECTOSIGMOID STRICTURE

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Abstract
An association between methysergide therapy for migraine and retroperitoneal fibrosis is documented and illustrated. The patient had bilateral ureteral obstruction, obstruction of the left common iliac vein, and rectosigmoid stricture—all secondary to the retroperitoneal fibrosis. Following withdrawal of the drug these obstructive lesions promptly improved. Follow-up clinical and roentgenographic studies indicated a return to essentially normal findings. Withdrawal of the drug is, in itself, usually effective therapy for any complication.

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