Comparison of the acute effect of the intranasal and intramuscular administration of salmon calcitonin in Paget's disease

Abstract
On 7 patients with mild-to-moderately active Paget's disease, 200 IU of salmon calcitonin (SCT) nasal spray (NS), induced a significant decrease of the total urinary hydroxyproline excretion (THP) during the 8–16 hour and the 0–24 hour (PPP<0.05). On 3 patients with severe Paget's disease, SCT-NS was essentially ineffective whereas the injection of SCT induced a marked diminution of the THP excretion.