Transcriptional induction of β‐galactoside α‐2,6‐sialyltransferase in rat fibroblast by dexamethasone
Open Access
- 1 January 1993
- journal article
- Published by Wiley in European Journal of Biochemistry
- Vol. 211 (1-2) , 135-140
- https://doi.org/10.1111/j.1432-1033.1993.tb19879.x
Abstract
The β-galactoside α-2,6-sialyltransferase activity of Fisher rat fibroblasts is enhanced by dexamethasone while the activity of the β-galactoside α-2,3-sialyltransferase remains unchanged. This glucocorticoid-dependent activation can be inhibited by the antagonist RU 38.486 and results from an elevated transcription rate of the 4.7-kb mRNA previously characterized in rat fibroblasts, distinct from the 4.3-kb liver-restricted mRNA. As shown by the binding of radiolabelled Sambucus nigra agglutinin, this activation leads to an increase of NeuNAc(α2–6)Gal sequences on glycoproteins isolated from the dexamethasone-treated cells.Keywords
This publication has 43 references indexed in Scilit:
- The c-Ha-ras oncogene induces increased expression of β-galactoside α-2,6-sialyltransferase in rat fibroblast (FR3T3) cellsGlycobiology, 1992
- Sticky sugars for selectinsNature, 1991
- Carbohydrate ligands of the LEC cell adhesion moleculesCell, 1990
- Rat β-galactoside α2,6-sialyltransferase genomic organization: alternate promoters direct the synthesis of liver and kidney transcriptsGlycobiology, 1990
- DNA regulatory elements for steroid hormonesJournal of Steroid Biochemistry, 1989
- Primary structure of two sialylated triantennary glycans from human serotransferrinFEBS Letters, 1985
- RU 38486: Potent antiglucocorticoid activity correlated with strong binding to the cytosolic glucocorticoid receptor followed by an impaired activationJournal of Steroid Biochemistry, 1984
- Anti-steroid action in cultured L-929 mouse fibroblastsJournal of Steroid Biochemistry, 1984
- Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphenylglycolurilBiochemical and Biophysical Research Communications, 1978
- Changed surface glycoprotein as a marker of malignancy in human leukaemic cellsNature, 1975