Polyfluoroheterocyclic compounds. Part XVI. Tetrafluoropyridine-3- and -4-carbaldehydes and some derivatives of the latter
- 1 January 1969
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society C: Organic
- No. 13,p. 1700-1703
- https://doi.org/10.1039/j39690001700
Abstract
Tetrafluoro-3- and -4-lithiopyridines behave normally in reacting with N-methylformanilide to give tetrafluoropyridine-3- and -4-carbaldehydes. The 4-carbaldehyde can be oxidised and reduced to the corresponding acid and carbinol respectively. It also reacts with pentafluorophenyl-lithium and tetrafluoro-4-lithiopyridine to give the corresponding secondary alcohols, which can be oxidised to pentafluorophenyl tetrafluoro-4-pyridyl and bis(tetrafluoro-4-pyridyl) ketones. The latter will react with more tetrafluoro-4-lithiopyridine to give tris(tetrafluoro-4-pyridyl)methanol, which can also be prepared from ethyl tetrafluoroisonicotinate and tetrafluoro-4-lithiopyridine.Keywords
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