Abstract
Fifty lumbar punctures were performed on each of three groups of leukemic children. The three categories studied were (1) those with central nervous system manifestations, (2) those free of symptoms following effective treatment, and (3) those not yet having developed central nervous system symptoms. The patients in Group I all had abnormal cerebrospinal fluid. Those examined before or between episodes referable to the central nervous system had normal findings, with rare exceptions. Positive results in the patients without symptoms almost always indicated the early recurrence of central nervous system symptoms.

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