Effect of antianaphylactic agents on substance-P induced histamine release from rat peritoneal mast cells
- 1 April 1988
- journal article
- research article
- Published by Springer Nature in Archives of Dermatological Research
- Vol. 280 (3) , 158-162
- https://doi.org/10.1007/bf00456847
Abstract
Substance P is known to be a potent histamine liberator for mast cells. The influence of antianaphylactic agents, disodium cromoglycate (DSCG), ketotifen, and tranilast was studied on substance-P and compound 48/80-induced histamine release from rat peritoneal mast cells. Substance-P induced histamine release was inhibited by these agents, while compound 48/80-induced histamine release was not inhibited by tranilast. Our findings suggest that these antianaphylactic agents are assumed to be effective for cutaneous diseases which might be concerned with substance P and histamine.Keywords
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