Effects of Fluconazole Administration in Critically Ill Patients

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Abstract
NOSOCOMIAL fungal infections in intensive care units (ICUs) are an increasingly prevalent problem. Infection caused by Candida species during the past decade has contributed to both longer hospitalizations and increased mortality. More than 50% of patients with fungal bloodstream infections will die as direct result of their infections or of their underlying disease.1-4 The severity of illness of hospitalized patients (immunocompromised or immunosuppressed), broad-spectrum antimicrobial administration, use of invasive devices, and advances in life-support systems have contributed to this trend.5-9