UGT pharmacogenomics
- 1 August 2003
- journal article
- review article
- Published by Wolters Kluwer Health in Pharmacogenetics
- Vol. 13 (8) , 517-523
- https://doi.org/10.1097/00008571-200308000-00010
Abstract
UDP-glucuronosyltransferases (UGTs) belong to a superfamily of microsomal enzymes responsible for glucuronidation of numerous endogenous and exogenous compounds including bilirubin, hormones, various drugs as well as environmental carcinogens. Glucuronidation predominantly serves as a pathway for elimination of the different glucuronidated compounds. Seventeen human UGT transcripts have been identified thus far, and the UGT proteins are differentially expressed in a wide-range of human tissues. Genetic variants have been identified in coding and non-coding sequences of several UGT genes, and similar observations should be anticipated for all UGTs. As glucuronidation plays a critical part in the inactivation or elimination of countless substrates, genetic variants in this enzyme family that lead to altered expression or activity of UGTs are likely to have some physiologic and pharmacological consequences. This article focuses on the potential impact of various UGTs or their variants on cancer risk and cancer therapeutics.Keywords
This publication has 54 references indexed in Scilit:
- An excretion balance and pharmacokinetic study of the novel anticancer agent E7070 in cancer patientsAnti-Cancer Drugs, 2002
- Pharmacogenetic analysis of adverse drug effect reveals genetic variant for susceptibility to liver toxicityThe Pharmacogenomics Journal, 2002
- Expression of UGT2B7, a UDP-Glucuronosyltransferase Implicated in the Metabolism of 4-Hydroxyestrone and All-Trans Retinoic Acid, in Normal Human Breast Parenchyma and in Invasive and in Situ Breast CancersThe American Journal of Pathology, 2002
- UGT1A1*28 polymorphism as a determinant of irinotecan disposition and toxicityThe Pharmacogenomics Journal, 2002
- An Allele-Specific Polymerase Chain Reaction Method for the Determination of the D85Y Polymorphism in the Human UDPGlucuronosyltransferase 2B15 Gene in a Case-Control Study of Prostate CancerAnnals of Surgical Oncology, 2000
- PharmacogeneticsClinical Pharmacokinetics, 2000
- Variations of the bilirubin uridine-diphosphoglucuronosyl transferase 1A1 gene in healthy TaiwanesePharmacogenetics, 2000
- Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes.Journal of Clinical Investigation, 1998
- Isolation and Characterization of a Novel cDNA Encoding a Human UDP-Glucuronosyltransferase Active on C19 SteroidsJournal of Biological Chemistry, 1996
- Pharmacokinetics of high dose etoposide (VP 16–213)European Journal of Cancer and Clinical Oncology, 1986