STUDY ON IGE LEVELS OF MILITARY RECRUITS AND ASSOCIATION WITH HLA ANTIGENS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 40  (5) , 319-321
Abstract
IgE determinations were performed on 58 recruits who were arbitrarily selected for HLA typing to identify antigen marker(s) on lymphocytes for the immunoregulation of Ig[immunoglobulin]E. Recruits (33) with IgE values ranging 24-142 U[units]/ml (71 U/ml average) showed a slight increase in incidence for HLA-A23, -A33 and BW-15 when compared to a group of 25 recruits whose IgE values ranged 153-2128 U/ml (615 U/ml average). Examination for C-loci specificity indicated that CW-1, CW-3 and CW-4 were similar from both groups; however, the low IgE group had a frequency of 55.5% of recruits possessing CW-2 antigen compared with only 15% for the ''high'' group. The value for the ''high'' IgE group appears to be similar to that of the normal population (10% incidence) and only slightly elevated when compared to 7% (2/29) found when the identical CW-2 antisera were tested with laboratory personnel. The associations of HLA-CW2 with the recruits within the ''low'' IgE group suggests that this HLA marker may be an expression for a suppressed response for IgE. Viral and bacterial infections, found frequently in these recruits, are discussed as a possible cause of this suppression.

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