IMMUNOFLUORESCENCE STUDIES WITH A SPECIFIC ANTISERUM TO MICROFIBRILLAR PROTEIN OF ELASTIC FIBERS - LOCATION IN ELASTIC AND NON-ELASTIC CONNECTIVE TISSUES

  • 1 January 1977
    • journal article
    • research article
    • Vol. 33  (3) , 381-386
Abstract
The microfibrillar protein (MFP) of fetal bovine ligamentum nuchae elastic fibers was prepared and used to produce a monospecific antiserum. Indirect immunofluorescence studies employing the specific antiserum demonstrated its selectivity for MFP associated with elastic fibers. The antiserum was demonstrated to react with vascular elastic tissue, perivascular connective tissue and reticular basement membranes in a variety of tissues. Apparently MFP (or an immunologically related protein) is not confined to elastic fibers but is widely distributed in connective tissue being associated with elastin and collagen fibers.