EFFECT OF PULMONARY ARTERY LIGATION ON THE HISTAMINE CONTENT OF LUNG, WITH OBSERVATIONS ON CONCOMITANT STRUCTURAL CHANGES
- 31 January 1948
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 152 (2) , 417-422
- https://doi.org/10.1152/ajplegacy.1948.152.2.417
Abstract
The deprivation of the pulmonary arterial inflow (mixed venous blood) to the right lower lobe of dogs'' lung was demonstrated to cause no significant decrease in extractable pulmonary histamine after periods of arterial ligation ranging from 2 wks. to 8 mo. This finding renders unlikely the hypothesis that the lung has a filtration or storage function with respect to histamine. Long-term pulmonary arterial ligation did not result in or decrease in collapsed vol. or wt. of the arterially ligated lobe as compared with the normal contralateral lobe. The expanded vol., however, was decreased due to interstitial fibrosis.Keywords
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