HOST GENETIC FACTORS INFLUENCING OCCURRENCE OF LEUKEMOID REACTION IN BALB-CMK MICE BEARING TRANSPLANTED TUMORS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 38  (12) , 4662-4664
Abstract
Host genetic factors influencing the occurrence of leukemoid reaction in BALB/cMk strain mice bearing transplanted tumors were studied. A Mendelian hybridization experiment was performed with BALB/cMk and C57BL/6 strains, and their strain hybrids: the F1 generation hybrids; F2 generation hybrids; and backcrosses to the 2 parental strains. A genetic regulation of leukemoid reaction occurrence in BALB/cMk mice bearing transplanted tumors was suggested. Genes permissive to the occurrence of the reaction seemed to be dominant to their nonpermissive alleles.