Regulation Of Cell Kinetics And Colon Cancer
- 4 June 2019
- book chapter
- Published by Taylor & Francis
- p. 199-214
- https://doi.org/10.1201/9780429263781-17
Abstract
Knowledge of the kinetics of epithelial cell populations in the normal and abnormal colon is obviously of potential importance in understanding colon cancer and in the designing of a rational therapy for this condition. However, it is really only in the last 20 years or so that any quantitative data in this area has been available, and two historical milestones preceded the acquisition of such knowledge. First, Ludford 1 and others in the late 1930s discovered the true effects of colchicine on dividing cells and, hence, established the background to stathmokinetic analysis of cell proliferation. Secondly, Howard and Pelc 2,3 in the early 1950s proposed the four-phase model of the cell cycle and initiated the use of autoradiographic detection of labeled DNA as a technique in cell kinetics.This publication has 0 references indexed in Scilit: