Attenuation of WNT signaling by DKK-1 and -2 regulates BMP2-induced osteoblast differentiation and expression of OPG, RANKL and M-CSF
Open Access
- 1 January 2007
- journal article
- Published by Springer Nature in Molecular Cancer
- Vol. 6 (1) , 71
- https://doi.org/10.1186/1476-4598-6-71
Abstract
Enhanced osteoblast-dependent osteoclastogenesis due to inhibition of Wnt/β-catenin signaling in bone morphogenic protein (BMP)-driven osteoprogenitors has been repeatedly implicated in the natural history of cancer-associated osteolytic lesions, but the mechanism of this bone loss is poorly understood.Keywords
This publication has 52 references indexed in Scilit:
- A Wnt canon orchestrating osteoblastogenesisTrends in Cell Biology, 2006
- Wnt/β-Catenin Signaling in Mesenchymal Progenitors Controls Osteoblast and Chondrocyte Differentiation during Vertebrate SkeletogenesisDevelopmental Cell, 2005
- Canonical Wnt/β-Catenin Signaling Prevents Osteoblasts from Differentiating into ChondrocytesDevelopmental Cell, 2005
- Sequential roles of Hedgehog and Wnt signaling in osteoblast developmentDevelopment, 2005
- Osteoclast differentiation and activationNature, 2003
- Metastasis to bone: causes, consequences and therapeutic opportunitiesNature Reviews Cancer, 2002
- Reaching a Genetic and Molecular Understanding of Skeletal DevelopmentDevelopmental Cell, 2002
- osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcificationGenes & Development, 1998
- Identity of Osteoclastogenesis Inhibitory Factor (OCIF) and Osteoprotegerin (OPG): A Mechanism by which OPG/OCIF Inhibits Osteoclastogenesisin Vitro1Endocrinology, 1998
- Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone DensityCell, 1997