Some 2, 3-Disubstituted 3H-4-Quinazolones and 3H-4-Thioquinazolones
- 1 September 1960
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 12 (1) , 529-538
- https://doi.org/10.1111/j.2042-7158.1960.tb12705.x
Abstract
Some 2-alkyl-3-aryl-3H-4-quinazolones (I; X = 0) have been prepared and a number of them converted into the thioquinazolones (I; X = S). A new method for the synthesis of 3-alkyl-2-aryl-3H-4-quinazolones (VI) has been developed and has been employed for the synthesis of representative derivatives. Biological study of the above compounds revealed that some of them, and in particular the 2-alkyl-3-halophenyl-3H-4-quinazolones are potent anticonvulsant agents.Keywords
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