Mixed Lymphocyte Culture Search for HLA-D Homozygous Typing Cells in the Hungarian Inbred Population of Ivád

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Abstract
Six functionally HLA-D homozygous typing cells were identified by a restricted investigation into the Hungarian inbred population of Ivad. These putative HLA-D homozygous typing cells were then tested against a highly selected Scandinavian population sample of 60 individuals previously typed by histocompatibility reference reagents. Three different HLA-D specificities were identified: one closely matching HLA-Dw5, another resembling the Oslo LDoH specificity, while the last seems to be unique. Only 1 of the typing cells thus ascertained were HLA-B homozygous and were selected on the basis of the Ivad family structure and not on the basis of serological HLA typing.