Age-related Changes in Plasma Proteins of Analbuminemic Rats
Open Access
- 1 January 1983
- journal article
- research article
- Published by Japanese Association for Laboratory Animal Science in Experimental Animals
- Vol. 32 (3) , 123-132
- https://doi.org/10.1538/expanim1978.32.3_123
Abstract
A mutant strain, Nagase analbuminemia rats (NAR), was established from Sprague-Dawley rats. Age-related changes in plasma proteins of NAR were investigated to obtain information concerning their abnormalities of protein metabolism. The total protein concentration in the serum of NAR or various ages was almost the same as that of normal rats of the same age. The albumin level of NAR was < 0.05 mg/ml at all ages examined. The concentrations of serum .alpha.1-antitrypsin, .alpha.-X protein, .alpha.2-macroglobulin, transferrin, ceruloplasmin, IgG, IgA and IgM were higher in NAR than in normal rats except for the perinatal stage, but .alpha.1-acid glycoprotein level in NAR was normal. The serum transferrin and ceruloplasmin levels were especially high in female adult NAR. The plasma fibrinogen concentration was also increased in NAR. The normal total serum protein level of NAR was evidently maintained by increase in the globulin concentration.This publication has 0 references indexed in Scilit: