Ciprofloxacin and Warfarin
- 15 September 1989
- journal article
- Published by American College of Physicians in Annals of Internal Medicine
- Vol. 111 (6) , 542-543
- https://doi.org/10.7326/0003-4819-111-6-542_2
Abstract
The recent letter by Linville and Matanin (1) brought attention to an interaction between norfloxacin (Noroxin, Merck Sharp & Dohme, West Point, Pennsylvania) and warfarin that resulted in an increased prothrombin time. We would like to report a case of a similar interaction between warfarin and ciprofloxacin (Cipro, Miles Inc., West Haven, Connecticut), another of the fluoroquinolone antibiotics. A 72-year-old white man with end-stage cardiomyopathy and a prosthetic aortic valve who was receiving chronic warfarin therapy was hospitalized with worsening congestive heart failure. He also had gout, type II diabetes mellitus, hypertension, chronic renal insufficiency, and hypothyroidism. In addition toKeywords
This publication has 2 references indexed in Scilit:
- Norfloxacin and WarfarinAnnals of Internal Medicine, 1989
- Displacement of warfarin from human albumin by diazoxide and ethacrynic, mefenamic, and nalidixic acidsClinical Pharmacology & Therapeutics, 1970