The inability of Angiotensin II infusions to raise plasma vasopressin levels in haemodialysis patients

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Abstract
Since it has previously been claimed that angiotensin II (AII) stimulates vasopressin (AVP) secretion, the effect of AII-infusions was studied in 6 normal, 5 non-nephrectomized hemodialysis (HD) patients, and 6 nephrectomized HD patients. In dialysis patients the infusion rate was increased step-wise from 2-12 ng AII/kg body wt .times. min-1 and was terminated if diastolic blood pressure (BP) increased more than 20 mmHg. Normals were infused at a constant rate of 4 ng AII/kg body wt .times. min-1. In all the groups significant increments in BP and plasma aldosterone occurred while plasma renin activity decreased. The plasma vasopressin level was unchanged in normals, while in the 2 groups of dialysis patients a minor decrease was found. The present study has not been able to confirm a stimulating effect of a physiological dose of AII on AVP secretion, and the results in anephric patients indicate that a normal plasma AII concentration is of no importance for the plasma AVP level.

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