Characterization of a new member of the human /-adaptin gene family from chromosome 22q12, a candidate meningioma gene
- 1 August 1994
- journal article
- research article
- Published by Oxford University Press (OUP) in Human Molecular Genetics
- Vol. 3 (8) , 1393-1399
- https://doi.org/10.1093/hmg/3.8.1393
Abstract
A 140 kb homozygous deletion from 22q12 In one menlngioma directed us towards the cloning and characterization of a new member of the human β-adaptln gene family (named BAM22). Adaptins are essential for the formation of clathrin coated vesicles in the course of intracellular transport of receptor-ligand complexes. The BAM22 gene is totally inactivated In the tumor with homozygous deletion. Northern blot analysis of 70 sporadic meningiomas showed specific loss of expression in 8 tumors, suggesting inactivation of BAM22. Based on this, we propose BAM22 as a second chromosome 22 locus Important in meningioma development, after the neuroflbromatosis type 2 gene.Keywords
This publication has 0 references indexed in Scilit: