STREPTOMYCIN COMBINED WITH SURGERY IN THE TREATMENT OF BONE AND JOINT TUBERCULOSIS

7 January 1950

journal article
research article
Published by American Medical Association (AMA) in JAMA

Vol. 142 (1) , 1-7
https://doi.org/10.1001/jama.1950.02910190003001

Abstract

Reports on the effect of streptomycin in the treatment of tuberculosis of bones and joints for the most part have been inconclusive or unpromising.¹Apparently most patients were treated with the antibiotic alone, without concomitant surgical measures. Brock,²Morgan and Bosworth³reported success with streptomycin in the treatment of tuberculous sinuses. Bickel and others⁴described 16 cases with streptomycin therapy, some in conjunction with fusion procedures, with 9 good results. These included 2 good results in synovial tuberculosis of the knee without surgical operation. Pulaski and associates⁵treated tuberculosis in 24 cases, 18 of the spine and 6 of the extremities, with 6 good results. Michele and Krueger reported success in 12 cases with the use of both streptomycin and surgery.⁶The largest and most carefully studied series of cases, with the best results, was that reported by Bosworth and others.⁷ The purpose

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