Inhibition of [3H]GABA Binding to Postsynaptic Receptors in Human Cerebellar Synaptic Membranes by Carboxyl and Amino Derivatives of GABA
- 5 October 1981
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 37 (4) , 837-844
- https://doi.org/10.1111/j.1471-4159.1981.tb04469.x
Abstract
Synthetic analog [50] of GABA were tested for their ability to interact with GABA receptors, using [3] GABA binding to human cerebellar membranes as an in vitro model. The most active compounds were aliphatic and heterocyclic aminosulfonic acids. Compounds with highly substituted N atoms were only weakly active unless a long alkyl chain, which can interact with the postsynaptic membrane, was present. A pyramidal N atom is probably favored for binding of GABA analogs to human cerebellar membranes.Keywords
This publication has 27 references indexed in Scilit:
- Piperidine‐4‐sulphonic Acid, a New Specific GAB A AgonistJournal of Neurochemistry, 1980
- Partial agonists for brain GABA/benzodiazepine receptor complexNature, 1979
- Conformational adaptability at GABA-sensitive inhibitory synapsesJournal of Theoretical Biology, 1975
- Electrophilic Reactions of 2- and 4-VinylpyridinesJournal of the American Chemical Society, 1947
- Studies in Chemotherapy. XV. Amides of Pantoyltaurine1Journal of the American Chemical Society, 1947
- The Conversion of 2-Phenyl-4-chloromethylthiazole to 2-Phenyl-4-hydroxymethyl-5-chlorothiazoleJournal of the American Chemical Society, 1943
- Studies in Chemotherapy. VII. A Theory of the Relation of Structure to Activity of Sulfanilamide Type Compounds1Journal of the American Chemical Society, 1942
- Explosion Hazard in the Chlorination of Alkyl Isothioureas to Prepare Alkyl Sulfonyl ChloridesJournal of the American Chemical Society, 1941
- Effect of Silver Ion Coördination upon the Raman Spectra of Some Unsaturated Compounds1Journal of the American Chemical Society, 1941
- THE ADDITION OF AMINO AND HYDRAZINO BASES TO NITROSTYRENE1Journal of the American Chemical Society, 1927