INHIBITION OF ULTRAVIOLET-B SKIN CARCINOGENESIS BY ALL-TRANS-RETINOIC ACID REGIMENS THAT INHIBIT ORNITHINE DECARBOXYLASE INDUCTION
- 1 January 1983
- journal article
- research article
- Vol. 43 (1) , 171-174
Abstract
There is a correlation between the ability to induce the polyamine-biosynthetic enzyme ornithine decarboxylase (ODC) and the tumor-promoting ability of various carcinogens in mouse epidermis. Some agents which inhibit skin carcinogenesis also inhibit ODC induction. In this study, all-trans-retinoic acid (RA) regimens that inhibited the induction of epidermal ODC by ultraviolet-B (UVB) were tested for their ability to inhibit UVB skin carcinogenesis. Hairless mice were irradiated once daily with UVB for 20 days, receiving a total dose of UVB (17.1 kJ/m2). Topical RA was applied immediately (RA, 1 dose) or applied 0, 1, 2, 3 and 4 h (RA, 5 doses) after each irradiance. The mice were maintained for 52 wk and then sacrificed. Groups treated with RA tended to have fewer mice with tumors, fewer tumors per mouse, smaller tumor diameters, and slower growing tumors than did appropriate irradiated control groups. RA given 5 times was more effective than was RA given 1 time at inhibiting UVB skin carcinogenesis. RA treatments that inhibit epidermal ODC induction may be effective in reducing the carcinogenicity of UVB.This publication has 3 references indexed in Scilit:
- Retinoic Acid Modulation of Ultraviolet Light-induced Epidermal Ornithine Decarboxylase ActivityJournal of Investigative Dermatology, 1982
- INHIBITION BY PROSTAGLANDIN SYNTHESIS INHIBITORS OF THE INDUCTION OF EPIDERMAL ORNITHINE DECARBOXYLASE ACTIVITY, THE ACCUMULATION OF PROSTAGLANDINS, AND TUMOR PROMOTION CAUSED BY 12-O-TETRADECANOYLPHORBOL-13-ACETATE1980
- TUMOR PROMOTION AND INDUCTION OF EPIDERMAL ORNITHINE DECARBOXYLASE ACTIVITY IN MECHANICALLY STIMULATED MOUSE SKIN1978