PHASE-I STUDY OF NEOCARZINOSTATIN IN CHILDREN WITH CANCER
- 1 January 1978
- journal article
- research article
- Vol. 62 (12) , 2105-2107
Abstract
Children (23) with advanced cancer refractory to conventional therapy received weekly i.v. doses of neocarzinostatin for 5 wk. Doses were escalated from 500 to 6750 units/m2 per wk. Four types of toxic manifestations occurred: acute reactions consisting of shaking chills with or without fever and cyanosis (rigor), hypersensitivity, vomiting and marrow depression. Evidence of oncolytic activity was limited to patients with acute leukemia in whom phase II trials at doses between 3000-4500 units/m2 appear warranted.This publication has 3 references indexed in Scilit:
- The relationship between DNA strand-scission and DNA synthesis inhibition in HeLa cells treated with neocarzinostatinBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1977
- Characterization of DNA strand breakage in vitro by the antitumor protein neocarzinostatinBiochemistry, 1977
- Mode of action of neocarzinostatin: Inhibition of DNA synthesis and degradation of DNA in Sarcina luteaBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1966