Regulation of the ferritin heavy‐chain homologue gene in the yellow fever mosquito, Aedes aegypti
- 26 April 2005
- journal article
- Published by Wiley in Insect Molecular Biology
- Vol. 14 (3) , 223-236
- https://doi.org/10.1111/j.1365-2583.2004.00550.x
Abstract
In the yellow fever mosquito Aedes aegypti, the ferritin heavy-chain homologue (HCH) gene is induced by blood feeding. This suggests that ferritin may serve as a cytotoxic protector against the oxidative challenge of the blood meal and may be essential for the survival of the insect. In this study, various cis-acting elements for the gene were identified and mapped. Transfection assays showed that the strength and activity of a subset of these elements are orientation-dependent. The shift observed for the ferritin HCH cis-acting elements is unique among known ferritin genes. DNase I footprinting data together with Transfac analyses identified a number of putative sites known for their involvement in developmental and cell proliferation processes.Keywords
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