Biodegradable xylitol‐based elastomers: In vivo behavior and biocompatibility
- 19 August 2010
- journal article
- research article
- Published by Wiley in Journal of Biomedical Materials Research Part A
- Vol. 95A (1) , 92-104
- https://doi.org/10.1002/jbm.a.32733
Abstract
Biodegradable elastomers based on polycondensation reactions of xylitol with sebacic acid, referred to as poly(xylitol sebacate) (PXS) elastomers have recently been developed. We describe the in vivo behavior of PXS elastomers. Four PXS elastomers were synthesized, characterized, and compared with poly(L-lactic-co-glycolic acid) (PLGA). PXS elastomers displayed a high level of structural integrity and form stability during degradation. The in vivo half-life ranged from approximately 3 to 52 weeks. PXS elastomers exhibited increased biocompatibility compared with PLGA implants. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2010Keywords
This publication has 24 references indexed in Scilit:
- In vitro and in vivo degradation of poly(1,3‐diamino‐2‐hydroxypropane‐co‐polyol sebacate) elastomersJournal of Biomedical Materials Research Part A, 2008
- Biodegradable poly(polyol sebacate) polymersBiomaterials, 2008
- Amino alcohol-based degradable poly(ester amide) elastomersBiomaterials, 2008
- The extracellular matrix as a biologic scaffold material☆Biomaterials, 2007
- In vitro homogeneous and heterogeneous degradation of poly(ε-caprolactone/polyethylene glycol/L-lactide): The absence of autocatalysis and the role of enzymesJournal of Biomedical Materials Research Part A, 2006
- Small-scale systems for in vivo drug deliveryNature Biotechnology, 2003
- Effect of Free Surfaces on the Glass Transition Temperature of Thin Polymer FilmsPhysical Review Letters, 1996
- Tissue EngineeringScience, 1993
- Long‐term evaluation of nerve regeneration in a biodegradable nerve guideMicrosurgery, 1993
- The enzymatic surface erosion of aliphatic polyestersJournal of Controlled Release, 1984