KIM127, an Antibody that Promotes Adhesion, Maps to a Region of CD18 that Includes Cysteine-Rich Repeats
- 1 January 1995
- journal article
- research article
- Published by Taylor & Francis in Cell Adhesion and Communication
- Vol. 3 (5) , 375-384
- https://doi.org/10.3109/15419069509081292
Abstract
A series of fusion proteins have been generated between human and mouse CD18. These proteins have been used to carry out preliminary mapping studies on a number of anti-CD18 antibodies including KIM127 an antibody that promotes CD18-dependent adhesion. This antibody maps to a region of the CD18 molecule between amino acids 406 and 570 in a region containing cysteine-rich repeats.Keywords
This publication has 33 references indexed in Scilit:
- Antibodies that activate β2 integrins can generate different ligand binding statesEuropean Journal of Immunology, 1995
- Structure/function analysis of the integrin beta 1 subunit by epitope mappingThe Journal of cell biology, 1993
- Biosynthesis and function of membrane bound and secreted forms of recombinant CD11b/CD18 (Mac‐1)Journal of Cellular Biochemistry, 1993
- The expression of CD11/CD18 molecules on rabbit leucocytes: Identification of monoclonal antibodies to CD18 and their effect on cellular adhesion processesMolecular Immunology, 1993
- Multiple functional forms of the integrin VLA-2 can be derived from a single alpha 2 cDNA clone: interconversion of forms induced by an anti-beta 1 antibody.The Journal of cell biology, 1993
- Integrins: Versatility, modulation, and signaling in cell adhesionCell, 1992
- Interaction of leukocyte integrins with ligand is necessary but not sufficient for function.The Journal of cell biology, 1992
- The gene organisation of the human β2 integrin subunit (CD18)FEBS Letters, 1991
- Up-regulation of the iC3b receptor (CR3) is neither necessary nor sufficient to promote neutrophil aggregation.Journal of Clinical Investigation, 1988
- Cloning of the $beta; subunit of the leukocyte adhesion proteins: Homology to an extracellular matrix receptor defines a novel supergene familyCell, 1987